The National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) is a national effort to accelerate the understanding of the molecular basis of cancer through the application of large-scale proteome and genome analysis, or proteogenomics. Data (genomics, proteomics, imaging), assays, and reagents are made available to the public as a Community Resource to accelerate cancer research and advance patient care. TCIA has partnered with CPTAC to host both the radiology and pathology imaging data generated by the project.1
CPTAC imaging data is being made available on a release schedule that is coordinated with the CPTAC program releases of proteomic and genomic data. Learn more about the CPTAC Discovery data sets here.
Accessing the Data
CPTAC Imaging Discovery Cohorts
Learn more about each cancer type by clicking on the collection names in the table below. Data currently available is listed below. Clicking on the number of subjects will take you to these data portals with that particular cancer type pre-selected. You can access the radiology and pathology data directly from the respective data portals.
| Collection | Cancer Type | Location | Radiology Modalities | **Radiology Total ** | Radiology Discovery | **Pathology Total ** | Pathology Discovery |
|---|---|---|---|---|---|---|---|
| CPTAC-CCRCC | Clear Cell Carcinoma | Kidney | CR, CT, DX, MR, SR | 63 | 32 | 222 | 110 |
| CPTAC-GBM | Glioblastoma Multiforme | Brain | CR, CT, DX, MR, NM, SC | 66 | 41 | 189 | 100 |
| CPTAC-HNSCC | Head and Neck Squamous Cell Carcinoma | Head-Neck | CT, SC, MR | 64 | 63 | 112 | 112 |
| CPTAC-LSCC | Squamous Cell Carcinoma | Lung | CR, CT, DX, NM, PT | 39 | 24 | 212 | 110 |
| CPTAC-LUAD | Adenocarcinoma | Lung | CT, MR, PT, CR, DX, NM | 33 | 15 | 244 | 111 |
| CPTAC-PDA | Pancreatic Ductal Adenocarcinoma | Pancreas | CR, CT, DX, MR, PT, RF, US, XA | 98 | 76 | 168 | 150 |
| CPTAC-UCEC | Corpus Endometrial Carcinoma | Uterus | CT, MR, PT, CR, DX | 74 | 21 | 250 | 101 |
Corresponding Genomic, Proteomic, and Clinical Data
The other data types will be hosted in separate tools and databases including:
- CPTAC Data Portal
- Proteomic Data Commons
- Genomic Data Commons
- CPTAC Python/R notebooks are available at https://github.com/PayneLab/cptac and on Google Colab at https://cutt.ly/ekMMht7.
CPTAC 2 Cohorts
| Collection | Cancer Type | Location | Pathology (Subjects) |
|---|---|---|---|
| CPTAC-BRCA | Breast Invasive Carcinoma | Breast | 134 |
| CPTAC-COAD | Colon Adenocarcinoma | Colon | 106 |
| CPTAC-OV | Ovarian Serous Cystadenocarcinoma | Ovary | 102 |
Citations2
CPTAC imaging data is considered CPTAC metadata. As such, it is freely available to the public according to the TCIA Data Usage Policy. Note that CPTAC proteomic and genomic data use must comply with the CPTAC Data Use Agreement.
For an overview of TCIA requirements, see License and attribution on the main TCIA page.
For information about accessing the data, see GCP data access.
Data citation
National Cancer Institute Clinical Proteomic Tumor Analysis Consortium (CPTAC). (2018). Radiology Data from the Clinical Proteomic Tumor Analysis Consortium Clear Cell Renal Cell Carcinoma [CPTAC-CCRCC] collection [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/k9/tcia.2018.oblamn27
National Cancer Institute Clinical Proteomic Tumor Analysis Consortium (CPTAC). (2018). Radiology Data from the Clinical Proteomic Tumor Analysis Consortium Cutaneous Melanoma [CPTAC-CM] collection [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/k9/tcia.2018.odu24gze
National Cancer Institute Clinical Proteomic Tumor Analysis Consortium (CPTAC). (2018). Radiology Data from the Clinical Proteomic Tumor Analysis Consortium Glioblastoma Multiforme [CPTAC-GBM] collection [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/k9/tcia.2018.3rje41q1
National Cancer Institute Clinical Proteomic Tumor Analysis Consortium (CPTAC). (2018). Radiology Data from the Clinical Proteomic Tumor Analysis Consortium Head and Neck Squamous Cell Carcinoma [CPTAC-HNSCC] Collection. The Cancer Imaging Archive. DOI: 10.7937/K9/TCIA.2018.UW45NH81
National Cancer Institute Clinical Proteomic Tumor Analysis Consortium (CPTAC). (2018). Radiology Data from the Clinical Proteomic Tumor Analysis Consortium Lung Squamous Cell Carcinoma [CPTAC-LSCC] Collection [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/k9/tcia.2018.6emub5l2
National Cancer Institute Clinical Proteomic Tumor Analysis Consortium (CPTAC). (2018). Radiology Data from the Clinical Proteomic Tumor Analysis Consortium Lung Squamous Cell Carcinoma [CPTAC-LSCC] Collection [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/k9/tcia.2018.6emub5l2
National Cancer Institute Clinical Proteomic Tumor Analysis Consortium (CPTAC). (2018). Radiology Data from the Clinical Proteomic Tumor Analysis Consortium Pancreatic Ductal Adenocarcinoma [CPTAC-PDA] Collection [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/k9/tcia.2018.sc20fo18
National Cancer Institute Clinical Proteomic Tumor Analysis Consortium (CPTAC). (2018). Radiology Data from the Clinical Proteomic Tumor Analysis Consortium Uterine Corpus Endometrial Carcinoma [CPTAC-UCEC] Collection [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/k9/tcia.2018.3r3juisw
National Cancer Institute Clinical Proteomic Tumor Analysis Consortium (CPTAC). (2020). Data from the Clinical Proteomic Tumor Analysis Consortium Breast Invasive Carcinoma [CPTAC-BRCA] collection [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/TCIA.CAEM-YS80
National Cancer Institute Clinical Proteomic Tumor Analysis Consortium (CPTAC). (2020). Data from the Clinical Proteomic Tumor Analysis Consortium Colon Adenocarcinom [CPTAC-COAD] collection [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/TCIA.YZWQ-ZZ63
National Cancer Institute Clinical Proteomic Tumor Analysis Consortium (CPTAC). (2020). Data from the Clinical Proteomic Tumor Analysis Consortium Ovarian Serous Cystadenocarcinoma [CPTAC-OV] collection [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/TCIA.ZS4A-JD58
Acknowledgment
The CPTAC program requests that publications using data from this program include the following statement: “Data used in this publication were generated by the National Cancer Institute Clinical Proteomic Tumor Analysis Consortium (CPTAC).”
TCIA citation
Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F. The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository, Journal of Digital Imaging, Volume 26, Number 6, December, 2013, pp 1045-1057. (paper)